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Both Lilith and The Guardian have different blindfolds that still function the same.

Repentance challenges: Scat Man, Baptism by Fire, and Hot Potato.

Afterbirth challenges: Blue Bomber, BRAINS! and The Guardian.

Rebirth challenges: Solar System, Cat Got Your Tongue, Beans!, and The Family Man.

Since blindfolded is a challenge condition instead of an existing item, it cannot be removed with Dice Rooms, Missing No., or D100, and does not show up on the 'My stuff!' screen, or be obtained with the debug menu. Despite being unable to fire tears, Isaac can still command familiars to shoot by holding the attack button, and can still use active items. However, this does not prevent attacks from items such as Maw of the Void or Revelation. It also prevents attacks from other firsthand sources, such as Mom's Knife, Brimstone, and Epic Fetus.

When Isaac is blindfolded, he is unable to fire tears and most projectiles. The characters Lilith and Tainted Lilith are also blindfolded.

Blindfolded is a special condition exclusive to certain challenges.

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